Screening and characterization of medicinal plants extracts with bactericidal activity against Streptococcus mutans |
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| Authors: | Alejandra Isabel Vargas-Segura Sonia Yesenia Silva-Belmares Elda Patricia Segura-Ceniceros Juan Alberto Ascacio-Valdés Luis Méndez-González |
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| Institution: | 1. Nanobioscience Group, Autonomous University of Coahuila, Saltillo, Coahuila, Mexico;2. Chemist Pharmacobiologist, Autonomous University of Coahuila, Saltillo, Coahuila, Mexico;3. Chemistry Engineering Group, Chemistry School, Autonomous University of Coahuila, Saltillo, Coahuila, Mexico;4. Dentistry School, Autonomous University of Coahuila, Saltillo, Coahuila, Mexico |
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| Abstract: | AbstractThe aim of the present study was to perform a screening of extracts obtained from 15 medicinal plants using water (at 25 and 90?°C) or ethanol (at 25?°C), to bactericidal activity against cariogenic S. mutans ATCC 25175, as well as to carry out the preliminary phytochemical characterization of the extracts and HPLC/MS assay for selected extracts. The extractions were carried out for 5?h at 400?rpm. Only five from 45 tested extracts were selected based on their antibacterial activity. The IC50 varied from of 28?ppm for Quercus ilex up to 250?ppm for Jatropha dioica. Different polyphenolic and quinic acids, flavonoids, anthocyanin or tyrosol were identified by HPLC/MS in selected extracts from Rosa gallica L., Jatropha dioica Sessé, Mimosa tenuiflora (Willd.) Poir, Quercus ilex L., and Solanum nigrum. The obtained results confirm that selected extracts are good candidates to be used for cariogenic bacteria control. |
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| Keywords: | Medicinal plant extracts Streptococcus mutans antibacterial activity HPLC/MS |
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