Rewiring cellular metabolism for heterologous biosynthesis of Taxol |
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Authors: | Amirhossein Nazhand Alessandra Durazzo Massimo Lucarini Maria Alessandra Mobilia Besma Omri |
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Institution: | 1. Biotechnology Department, Sari University of Agricultural Sciences and Natural Resources, Mazandaran, Sari, Iran;2. nazhand.ah@gmail.comhttps://orcid.org/0000-0001-5505-3327;4. CREA-Research Centre for Food and Nutrition, Rome, Italy;5. Freelance Medical Doctor, Messina, Italy;6. Laboratory of Improvement &7. Integrated Development of Animal Productivity &8. Food Resources, Higher School of Agriculture of Mateur, University of Carthage, Bizerte, Tunisia |
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Abstract: | AbstractTaxol is one of the anticancer drugs synthesized naturally in the evergreen Taxus brevifolia forest tree belonging to the yew family (Taxaceae) growing on the Pacific. There are reportedly evidence for treating ovarian, breast and lung cancers through this drug given its unique structural and functional features. Extraction of this drug from yew trees bark is one of the most common ways of producing this drug, but 3000 trees are needed to obtain a kilogram of Taxol. Hence, further attention has recently been attracted to the metabolic engineering strategies, including, engineering cellular metabolism of microorganisms and their optimization. Accordingly, the present paper article was aimed to review recent advances in elevating the production and commercialization of Taxol through metabolic engineering techniques. |
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Keywords: | Taxol Metabolic Engineering Anticancer Drugs Natural Products |
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