Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus |
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| Authors: | Thanika Promchai Pawinee Janhom Wisanu Maneerat Roonglawan Rattanajak Sumalee Kamchonwongpaisan Stephen G Pyne |
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| Institution: | 1. Department of Chemistry and Center of Excellence for Innovation in Chemistry Faculty of Science, Chiang Mai University, Chiang Mai, Thailand;2. The Graduate School, Chiang Mai University, Chiang Mai, Thailand;3. School of Science, Mae Fah Luang University, Chiang Rai, Thailand;4. Medical Molecular Biology Research Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani, Thailand;5. School of Chemistry, University of Wollongong, Wollongong, New South Wales, Australia |
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| Abstract: | AbstractA new 2-arylbenzofuran, spathobenzofuran (1), together with ten known compounds including a 2-arylbenzofuran, three pterocarpans and six isoflavones were isolated from the acetone crude extract of the stems of Spatholobus parviflorus. All compounds were characterised by spectroscopic methods. Compound 4 was active (MIC 8?µg/mL) against Gram-negative Pseudomonas aeruginosa TISTR 781 while compound 2 had modest activity against Gram-positive Staphylococcus aureus TISTR 1466 with a MIC value of 16?µg/mL. All isolated compounds showed no cytotoxicity against Vero and KB cells. |
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| Keywords: | Spatholobus parviflorus arylbenzofuran antibacterial activity cytotoxicity |
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