A new diterpenoid alkaloid from Aconitum hemsleyanum |
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| Authors: | Zhi-Hui Luo Yang Chen Xin-Yi Sun Hua Fan Wei Li |
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| Affiliation: | 1. Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zunyi Medical University Zhuhai Campus, Zhuhai, China;2. School of Pharmaceutical Science &3. Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China |
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| Abstract: | ![]()
AbstractA new C19-diterpenoid alkaloid named hemsleyaline (1), along with fourteen known alkaloids (2-15), were isolated from the roots of Aconitum hemsleyanum Pritz. (Ranunculaceae), a herbal medicine in southwest China. Their structures were established on the basis of extensive spectroscopic analyses. Compound 1 showed mild cholinesterase inhibitory effect with IC50 value of 471?±?9?μM. |
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| Keywords: | Aconitum hemsleyanum Ranunculaceae diterpenoid alkaloid cholinesterase inhibitory effect |
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