New cytotoxic constituents in the water-soluble fraction from Momordicae Semen |
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| Authors: | Meng-Yue Wang Zhi-Bin Zhan Ying Xiong Hao Zhang |
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| Institution: | 1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China;2. College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China;3. College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, China |
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| Abstract: | AbstractTwo new lignans mubezhisol (1) and mubezhisal (2), together with twenty six known compounds (3–28) were isolated from water-soluble fraction from the semens of Momordica cochinchinensis. In the subsequent action evaluation, four saponins (4, 6, 13, 27), six lignans (1, 2, 16, 17, 22, 23), and one naphthoquinone (24) exhibited the significant cytotoxicity. The results indicated that various saponins and lignans were mainly responsible for the antitumor activities of Momordicae Semen. |
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| Keywords: | Momordica cochinchinensis water-soluble constituents lignan cytotoxic |
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