A new macrocyclic diterpenoid from Anisomeles indica |
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| Authors: | Chen-Liang Chao Hui-Chi Huang Hsiou-Yu Ding Jenn-Haung Lai Hang-Ching Lin |
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| Affiliation: | 1. Research &2. Development Center, Sinphar Pharm. Co., Ltd., I-Lan , Taiwan;3. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung , Taiwan;4. Department of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan , Taiwan;5. Rheumatology/Immunology and Allergy, Department of Medicine, Tri-Service General Hospital, Taipei , Taiwan;6. School of Pharmacy, National Defense Medical Center, Taipei , Taiwan |
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| Abstract: | ![]()
AbstractA new macrocyclic diterpenoid, 4β,5β-dihydroxyovatodiolide (1), together with twenty-two known compounds (2-23) were isolated from the MeOH extract of the dried aerial parts of Anisomeles indica (L.) O. Kuntze (Labiatae). The structure of 1 was established on the basis of spectral evidence. Phenylethanoids, acteoside (5) and isoacteoside (6) showed significant inhibitory to IL-2 secretion of with respect to phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood T cells. |
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| Keywords: | Anisomeles indica labiatae 4β,5β-dihydroxyovatodiolide anti-arthritis activity |
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