Microporotriol,a new cadinane-type sesquiterpenoid from the cultures of the wood-decay fungus Microporus affinis HFG829 |
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| Authors: | Zhen-Zhu Zhao Ji-Kai Liu |
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| Institution: | 1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China;2. Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment &3. Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China;4. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, People’s Republic of China;5. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People’s Republic of China |
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| Abstract: | AbstractA new cadinane-type sesquiterpenoid, microporotriol (1), together with four known compound, 5-methylresorcinol (2), (22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (3), (22E,24R)-ergosta-5,7,22-trien-3β-ol (4), (22E,24R)-5α,8α-epidioxy-ergosta-6,22-dien-3β-ol (5), were isolated from the fermentation broth of the wood decaying fungus Microporus affinis HFG829. The structures of the compounds were established by extensive spectroscopic methods, including 1D & 2D NMR, along with HRMS spectroscopic analysis. The relative configuration of 1 was confirmed by NMR calculation. Compound 1 was evaluated for the cytotoxicity against five human cancer cell lines. |
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| Keywords: | Microporus affinis HFG829 polyporaceae secondary metabolite cadinane sesquiterpenoid |
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