Synthesis of 2-phenoxyl-2-oxo-1,4,2-oxazaphosphinanes from a three component reaction |
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| Authors: | Wenjie Zhang Xiling Ding Zijie Li Xiaolan Chen Yufen Zhao |
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| Institution: | 1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China;2. zwj9007@163.com;4. Danhong Pharmaceutical, Shandong Danhong Pharmaceutical Co., Ltd, Heze, China;5. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China;6. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China;7. Department of Chemistry, Xiamen University, Xiamen, China |
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| Abstract: | AbstractA one-pot synthetic strategy was developed for the synthesis of heterocyclic 1,4,2-oxazaphosphinanes via a three component Kabachnik-Fields reaction of 2-aminophenol, diphenyl H-phosphonate and carbonyl compounds. Through this newly developed method, 12 organophosphorus heterocycles and 2 related chrysin derivatives were synthesized with high yields. The target compounds were characterized by 1H, 31P and 13C NMR and MS. |
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| Keywords: | Organophosphorus heterocycles 1 4 2-oxazaphosphinanes chrysin derivatives H-phosphonates Kabachnik-Fields reaction |
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