Quassinoids from seeds of Brucea Javanica and their anticomplement activities |
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| Authors: | Yanzhi Zhan Ting Tan Kai Qian Shilin Yang |
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| Institution: | 1. Jiangxi University of Traditional Chinese Medicine, Nanchang, China;2. State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Nanchang, China |
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| Abstract: | AbstractAn investigation on seeds of Brucea javanica led to the acquisition of a new quassinoid, 20-hydroxyyadanzigan (1), along with five known quassinoids (2–6). The structure of the new compound was elucidated on the basis of extensive spectral analysis. All of the compounds were assayed for their anticomplement activities through classical and alternative pathways. Compounds 1–6 exhibited potent anticomplement activity with CH50 and AP50 values of 0.032–0.075?mg/mL and 0.061–0.118?mg/mL, respectively. Moreover, the structure-activity relationships of these compounds are discussed. | |
| Keywords: | Brucea javanica quassinoids anticomplement activity |
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