Fluevirines E and F,two new alkaloids from Flueggea virosa |
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| Authors: | Xi Yang Jianwen Liu Zongqing Huo Huansha Yuwen |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Guizhou University, Guiyang, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany Chinese Academy of Sciences, Kunming, China;3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany Chinese Academy of Sciences, Kunming, China |
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| Abstract: | AbstractTwo new alkaloids, fluevirines E (1) and F (2), along with six known Securinega alkaloids, were isolated from the methanol extract of the twigs and leaves of Flueggea virosa. The structures and absolute configurations of the new compounds were elucidated by means of MS, NMR, and ECD analyses. Compound 1 is a new dimeric indole alkaloid while 2 is a new securinega-type alkaloid. The in vitro cytotoxic activities of the isolated alkaloids against several human cancer cell lines and their acetylcholinesterase inhibitory activity were also evaluated. |
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| Keywords: | Flueggea virosa fluevirine E fluevirine F alkaloids |
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