Prenylated isoflavones with potential antiproliferative activities from Mappianthus iodoides |
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| Authors: | Yan-Ping Liu Li-Li Sun Xiang-Lin Zhang Hai-Yuan Niu Zheng-Hong Pan |
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| Institution: | 1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;2. Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China;3. Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin, P. R. China |
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| Abstract: | Abstract A phytochemical investigation on the stems of Mappianthus iodoides led to the isolation of a new naturally occurring prenylated isoflavone, mappianthone A (1), together with seven known analogues (2?8). The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. All isolated compounds were evaluated for their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1?8 showed significant antiproliferative effects against several human cancer cell lines with IC50 values ranging from 0.16 to 12.68?μM.  | |
| Keywords: | antiproliferative activities Mappianthus iodoides mappianthone A prenylated isoflavone |
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