Chemical constituents and cytotoxic activity from the wood-decaying fungus Xylaria sp. SWUF08-37 |
| |
| Authors: | Somchai Noppawan Wiyada Mongkolthanaruk Nuttika Suwannasai Thanaset Senawong Pairot Moontragoon Jaursup Boonmak |
| |
| Institution: | 1. Natural Products Research Unit, Department of Chemistry and Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Khon Kaen University, Khon Kaen, Thailand;2. Department of Microbiology, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand;3. Department of Biology, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand;4. Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand;5. Department of Physics, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand;6. Materials Chemistry Research Center, Department of Chemistry and Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Khon Kaen University, Khon Kaen, Thailand |
| |
| Abstract: | AbstractA new cyclic pentapeptide, pentaminolarin (1), and a new cytochalasin, xylochalasin (2), along with thirteen known compounds (3–15) were isolated from the wood-decaying fungus Xylaria sp. SWUF08-37. The absolute configurations of 1 were determined by a combination of Marfey’s method and TDDFT ECD calculation and the absolute configurations of 2 were established by TDDFT ECD calculation. Compound 12 showed moderate cytotoxicity against HeLa (IC50?=?19.60?µg/mL), HT29 (IC50?=?17.31?µg/mL), HCT116 (IC50?=?14.28?µg/mL), MCF-7 (IC50?=?15.38?µg/mL), and Vero (IC50?=?24.97?µg/mL) cell lines by MTT assay. Compounds 1 and 2 showed slight cytotoxicity against all tested cancer cell lines. |
| |
| Keywords: | Xylariaceae wood decaying fungus cyclic pentapeptide cytochalasin cytotoxic activity |
|
|
