Neuroprotective terpenoids from the leaves of Viburnum odoratissimum |
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| Authors: | Yan Zhang Wei-Yu Zhou Xiao-Yu Song Guo-Dong Yao |
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| Institution: | School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China |
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| Abstract: | AbstractAs a part of our ongoing search for neuroprotective compounds from natural products, two new iridoid glycosides, vibsansuspenside A-B (1-2), along with five known terpenoids (3-7), were isolated from the dry leaves of Viburnum odoratissimum. Their chemical structures were well determined by means of NMR spectroscopic data as well as HRESIMS analysis. All compounds were detected for their neuroprotective effects against H2O2-induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y). Among them, compound 3 displayed the most potent neuroprotective ability, and further investigation by Annexin V/PI and Western blot analysis demonstrated that compound 3 could protect SH-SY5Y cells from oxidative damage through inhibiting cell apoptosis. | |
| Keywords: | Viburnum odoratissimum Terpenoids neuroprotective activity apoptosis |
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