Organometallic and enzymatic catalysis for ring opening copolymerization of ε‐caprolactone and 4‐methyl‐ε‐caprolactone |
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| Authors: | Cui Wang Yan Xiao Andreas Heise Meidong Lang |
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| Institution: | 1. Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China;2. Dublin City University, School of Chemical Sciences, Glasnevin, Dublin 9, Ireland |
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| Abstract: | A series of copolymers containing ε‐caprolactone (CL) and 4‐methyl‐ε‐caprolactone (MeCL) were synthesized by ring‐opening polymerization (ROP) using Tin(II) bis(2‐ethylhexanoate)(Sn(Oct)2) or Novozym 435 as catalyst. The molecular structure and weight of copolymers were determined by nuclear magnetic resonance (NMR) and size exclusion chromatography (SEC), respectively. Our kinetic study showed that the monomer reactivity ratios for CL (r1) and MeCL (r2) using Sn(Oct)2 as catalyst were estimated to be near unity and r1 × r2 = 1, indicating the random distribution of the monomers in the final copolymer. The results of DSC and XRD consistently indicated that the copolymers were inclined to be amorphous with the increasing of MeCL fraction. Microspheres were prepared from copolymers and characterized by SEM. The preliminary degradability and biocompatibility studies on these copolymers were also assessed. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011 |
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| Keywords: | degradation enzymatic catalysis kinetics (polym ) particle formation ring‐opening polymerization |
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