Nukiangendines A and B,two novel 13,14-seco-abietanes from Abies nukiangensis |
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| Authors: | Yong-Li Li Qiang Zhang Jian-Jun Wu Li-Jun Xue Li-Ming Chen Jun-Mian Tian Zhuo-Ni Xu Ying Chen Xian-Wen Yang Xiao-Jiang Hao Jie Li |
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| Affiliation: | 1. Physical and Chemical Analysis Laboratory, Division of Material Science & Quality Test, Shanghai Institute of Measurement and Testing Technology, 1500 Zhangheng Road, Shanghai 201203, China;2. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University, 3 Taicheng Road, Yangling 712100, China;3. Department of Medical Oncology, Jinling Hospital, Nanjing University Clinical School of Medicine, 305 East Zhongshan Road, Nanjing 210002, China;4. Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China;5. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China |
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| Abstract: | From Abies nukiangensis, two novel 13,14-seco-abietane diterpenes, nukiangendines A (1) and B (2) were isolated. Their relative structures were determined by extensive NMR and HRMS spectroscopic analysis. The absolute configuration of 1 was established by ECD calculations. Compound 1 showed significant anti-hepatitis C virus (HCV) effects. |
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| Keywords: | Diterpene Antiviral |
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