| 胆汁酸盐对胆红素钙沉淀过程的影响 |
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| 引用本文： | 王夔,卓济苍,许善锦,胡加平. 胆汁酸盐对胆红素钙沉淀过程的影响[J]. 无机化学学报, 1992, 8(3): 235-239 |
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| 作者姓名： | 王夔 卓济苍 许善锦 胡加平 |
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| 作者单位： | 天然药物及仿生药物国家重点实验室，天然药物及仿生药物国家重点实验室，北京医科大学无机化学教研室，北京医科大学无机化学教研室 北京 100083，北京 100083，北京 100083，北京 100083 |
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| 摘 要： | 研究了六种人胆汁主要胆汁酸盐对胆红素钙沉淀形成过程的影响。用曲线拟合法处理数据取得热力学及动力学参数。结果表明,六种胆汁酸盐都表现动力学和热力学抑制,而且抑制作用有浓度依赖关系。在一定条件下出现诱导期。虽然不同胆汁酸盐的作用结果相似,但在相同条件下,二羟基胆汁酸和三羟基胆汁酸影响程度不同。
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| 关 键 词： | 胆红素钙 胆汁酸盐 沉淀 |
| 收稿时间： | 1990-09-12 |
EFFECTS OF BILE SALTS ON THE PRECIPITATION PROCESS OF CALCIUM BILIRUBINATE |
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| Wang Kui,Zhuo Jicang,Xu Shanjin and Hu Jiaping. EFFECTS OF BILE SALTS ON THE PRECIPITATION PROCESS OF CALCIUM BILIRUBINATE[J]. Chinese Journal of Inorganic Chemistry, 1992, 8(3): 235-239 |
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| Authors: | Wang Kui Zhuo Jicang Xu Shanjin Hu Jiaping |
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| Affiliation: | Research Laboratories of Natural and Biomimetic Drugs, Beijing 100083,Research Laboratories of Natural and Biomimetic Drugs, Beijing 100083,Department of Inorganic Chemistry, Beijing Medical University, Beijing 100083 and Department of Inorganic Chemistry, Beijing Medical University, Beijing 100083 |
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| Abstract: | The effects of six bile salts on the precipitation formation process of calcium bilirubinate were studied by means of measuring the light scattering of the reaction mixtures in the presence of various bile salts of different concentrations. The data were treated by curve-fitting method and the kinetic and thermodynamic parameters were obtained and compared. The results show that all the bile salts inhibit the reaction thermodynamically and kinetically and the inhibition effect was found to be concentration-dependent. An induction period was observed under certain conditions. Although similar results were obtained from various bile salts, the affects of dihydroxycholates and trihydroxycholates are different under same conditions. This diversity was discussed on the ground of the hydrophobicity and micelle formation. |
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| Keywords: | calcium biiirubinate bile salt |
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