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| 乳香大环二萜类化学成分研究 | |
| 引用本文： | 李福双,徐康平,袁寿洪,颜冬兰,刘让如,谭健兵,曾光尧,周应军,谭桂山.乳香大环二萜类化学成分研究[J].有机化学,2010,30(1):107-111. |
| 作者姓名： | 李福双 徐康平 袁寿洪 颜冬兰 刘让如 谭健兵 曾光尧 周应军 谭桂山 |
| 作者单位： | 1. 中南大学药学院,长沙,410013 2. 中南大学湘雅医院药剂科,长沙,410008 3. 中南大学药学院,长沙,410013;中南大学湘雅医院药剂科,长沙,410008 |
| 基金项目： | 湖南省科技厅资助项目（编号：06sk3001） |
| 摘 要： | 采用硅胶柱层析,制备薄层层析等色谱方法,从乳香CO_2超临界提取物中分得7个大环二萜类化合物,经波谱方法鉴定为incensole acetate(1),incensole(2),incensole oxide acetate(3),isoincensole acetate(4),incensole oxide(5),isoincensoleoxide(6),isoincensolol(7),其中,化合物7为新化合物,化合物4为首次从该属植物中分离得到.采用四甲基偶氮唑蓝(MTT)法观察化合物对肿瘤细胞的抑制增殖作用. |
| 关 键 词： | 乳香 化学成分 大环二萜 抗肿瘤 isoincensoleol |
| 收稿时间： | 2008-09-24 |
| 修稿时间： | 2009-04-24 |
Macrocyclic Diterpenes from Boswellia carterii Birdwood (Frankincense) |
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| Li Fushuang,Xu Kangping,Yuan Shouhong,Yan Donglan,Liu Rangru,Tan Jianbing,Zeng Guangya,Zhou Yingjun,Tan Guishan.Macrocyclic Diterpenes from Boswellia carterii Birdwood (Frankincense)[J].Chinese Journal of Organic Chemistry,2010,30(1):107-111. | |
| Authors: | Li Fushuang Xu Kangping Yuan Shouhong Yan Donglan Liu Rangru Tan Jianbing Zeng Guangya Zhou Yingjun Tan Guishan |
| Institution: | ( School of Pharmaceutical Sciences，Central South University，Changsha 410013) ( Department of Pharmacy，Xiangya Hospital，Central South University，Changsha 410008) |
| Abstract: | Seven macrocyclic diterpene compounds were isolated from Boswellia carterii Birdwood (Frankincense)and purified by silica-gel column chromatorgraphy and preparative thin-layer chromatography(TLC).Their structures were elucidated as incensole acetate(1),incensole(2),incensole oxide acetate (3),isoincensole acetate(4),incensole oxide(5),isoincensole oxide(6)and isoincensolol(7).Compound 7 was a novel compound and compound 4 was isolated from this genus for the first time.Compounds 1～7suppressing Bel-7402,Hela and SW-480 cells were investigated in vitro with cytotoxic activity. |
| Keywords: | Boswellia carterii Birdwood (Frankincense) chemical constituent macrocyclic diterpene anti-tumor isoincensolol |
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