New one-pot, efficient, and regioselective method for the synthesis of 3-Trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs |
| |
Authors: | Helio G Bonacorso Michele S CorreaLiliane MF Porte Everton P PittalugaNilo Zanatta Marcos AP Martins |
| |
Institution: | Núcleo de Química de Heterociclos-NUQUIMHE, Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil |
| |
Abstract: | An efficient and regioselective procedure for the synthesis of a series of alkyl(aryl/heteroaryl) substituted 3-trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs, from the cyclocondensation reactions of 4-alkoxy-1,1,1-trihaloalk-3-en-2-ones CX3C(O)CR2=CR1(OMe/OEt), where R1 = H, Me, Ph, 2-Furyl; R2 = H; R1-R2 = -C4H8- and X = F, Cl] and 1-phenylsemicarbazide in an acidified alcoholic medium (R3OH/H2SO4), where R3 = Me, Et, Pri was successfully applied and is described here in detail. |
| |
Keywords: | Phenylpyrazoles 3-Trifluoromethylpyrazoles Esterification reactions Cyclization reactions Phenylsemicarbazides |
本文献已被 ScienceDirect 等数据库收录! |
|