A stochastic model for retinocollicular map development |
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Authors: | Alexei A Koulakov and Dmitry N Tsigankov |
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Institution: | (1) Cold Spring Harbor Laboratory, One Bungtown Road, 11724 Cold Spring Harbor, NY, USA |
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Abstract: | Background We examine results of gain-of-function experiments on retinocollicular maps in knock-in mice Brown et al. (2000) Cell 102:77].
In wild-type mice the temporal-nasal axis of retina is mapped to the rostral-caudal axis of superior colliculus. The established
map is single-valued, which implies that each point in retina maps to a unique termination zone in superior colliculus. In
homozygous Isl2/EphA3 knock-in mice the map is double-valued, which means that each point on retina maps to two termination
zones in superior colliculus. This is because about 50 percent of cells in retina express Isl2, and two types of projections,
wild-type and Isl2/EphA3 positive, form two branches of the map. In heterozygous Isl2/EphA3 knock-ins the map is intermediate
between the homozygous and wild-type: it is single-valued in temporal and double-valued in the nasal parts of retina. In this
study we address possible reasons for such a bifurcation of the map. |
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