| Actinolactomycin,a New 2-Oxonanonoidal Antitumor Antibiotic Produced by Streptomyces flavoretus 18522,and its Inhibitory Effect on the Proliferation of Human Cancer Cells |
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| 引用本文： | Bing HAN1,2,Cheng Bin CUI1,4*,Bing CAI3,Xiu Feng JI2,3,Xin Sheng YAO2 1Beijing Institute of Pharmacology and Toxicology,AMMS,Beijing 100850 2 Shenyang Pharmaceutical University,Shengyang 110016 3Tianjin Institute for Biomedicinal Research (TIBiR),Tanjin 300384 4Marine Drug and Food Institute,Ocean University of China,Qingdao 266003. Actinolactomycin,a New 2-Oxonanonoidal Antitumor Antibiotic Produced by Streptomyces flavoretus 18522,and its Inhibitory Effect on the Proliferation of Human Cancer Cells[J]. 中国化学快报, 2005, 16(4) |
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| 作者姓名： | Bing HAN1 2 Cheng Bin CUI1 4* Bing CAI3 Xiu Feng JI2 3 Xin Sheng YAO2 1Beijing Institute of Pharmacology and Toxicology AMMS Beijing 100850 2 Shenyang Pharmaceutical University Shengyang 110016 3Tianjin Institute for Biomedicinal Research (TIBiR) Tanjin 300384 4Marine Drug and Food Institute Ocean University of China Qingdao 266003 |
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| 摘 要： | In the course of our screening for new anticancer agents from microbial resources usingmammalian cancer tsFT210 cells1-3, we found that the fermentation broth of anactinomycete strain 18522 significantly inhibited the cell cycle of tsFT210 cells at theG0/G1 phase. From the fermentation broth of this strain, we have now isolated a new2-oxonanonoidal anitumor antibiotic, named actinolactomycin 1, through a bioassay-guided separation procedure. In this communication, the isolation, structure de…
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Actinolactomycin, a New 2-Oxonanonoidal Antitumor Antibiotic Produced by Streptomyces flavoretus 18522, and its Inhibitory Effect on the Proliferation of Human Cancer Cells |
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| Bing HAN,,Cheng Bin CUI,,Bing CAI,Xiu Feng JI,,Xin Sheng YAO Beijing Institute of Pharmacology and Toxicology,AMMS,Beijing Shenyang Pharmaceutical University,Shengyang Tianjin Institute for Biomedicinal Research. Actinolactomycin, a New 2-Oxonanonoidal Antitumor Antibiotic Produced by Streptomyces flavoretus 18522, and its Inhibitory Effect on the Proliferation of Human Cancer Cells[J]. Chinese Chemical Letters, 2005, 16(4) |
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| Authors: | Bing HAN Cheng Bin CUI Bing CAI Xiu Feng JI Xin Sheng YAO Beijing Institute of Pharmacology Toxicology AMMS Beijing Shenyang Pharmaceutical University Shengyang Tianjin Institute for Biomedicinal Research |
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| Abstract: | |
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| Keywords: | Actinolactomycin 2-oxonanonoid structure antitumor agent cell cycle inhibitor apoptosis inducer Streptomyces flavoretus. |
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