Dry and wet prolines for asymmetric organic solvent-free aldehyde-aldehyde and aldehyde-ketone aldol reactions |
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Authors: | Hayashi Yujiro Aratake Seiji Itoh Takahiko Okano Tsubasa Sumiya Tatsunobu Shoji Mitsuru |
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Institution: | Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo, 162-8601, Japan. hayashi@ci.kagu.tus.ac.jp |
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Abstract: | Dry and wet prolines were found to catalyze the direct aldol reactions of aldehyde-aldehyde and aldehyde-ketone, respectively, to afford aldols with excellent diastereo- and enantioselectivities, and an organic solvent-free reaction was realized in some cases. |
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