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A phase I, randomized study of combined IL-2 and therapeutic immunisation with antiretroviral therapy |
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| Authors: | Gareth AD Hardy Nesrina Imami Mark R Nelson Ann K Sullivan Ron Moss Marlén MI Aasa-Chapman Brian Gazzard Frances M Gotch |
| Institution: | (1) Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK;(2) Department of HIV/GU Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK;(3) Immune Response Corporation, Carlsbad, CA, USA;(4) Wohl Virion Centre, Windeyer Institute of Medical Sciences, UCL, London, W1T 4JF, UK |
| Abstract: | BackgroundFully functional HIV-1-specific CD8 and CD4 effector T-cell responses are vital to the containment of viral activity and disease progression. These responses are lacking in HIV-1-infected patients with progressive disease. We attempted to augment fully functional HIV-1-specific CD8 and CD4 effector T-cell responses in patients with advanced chronic HIV-1 infection. |
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