Cytotoxic Activity of Some Novel Dicoumarin Derivatives in vitro |
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| Authors: | ZHANG Hui YU Tian-zhi ZHAO Yu-ling FAN Duo-wang DING Lan ZHANG Shi-dong Key Laboratory of Opto-Electronic Technology Intelligent Control Ministry of Education School of Chemical Biological Engineering Lanzhou Jiaotong University Lanzhou P R China College of Life Science Northwest Normal University |
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| Institution: | [1]Key Laboratory of Opto-Electronic Technology and Intelligent Control, Ministry of Education [2]School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, P. R. China [3]College of Life Science, Northwest Normal University, Lanzhou 730070, P. R. China |
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| Abstract: | Some novel dicoumarin derivatives, triethylene-glycol dibenzo5,6] coumarin-3-carboxylate(1a),PEG (600) dibenzo5,6]coumarin-3-carboxylate(1b), triethylene-glycol di7-(N,N'-diethylamino)]-coumarin-3-carboxylate(2a), were synthesized. The cytotoxic effect of these compounds, along with benzo5,6]coumarin-3-carboxylic acid(1) and 7-(N,N'-diethylamino)-coumarin-3-carboxylic acid(2), against the SGC-7901 cell lines were determined by Sulforhodamine B(SRB) assay. The preliminary cytotoxicity screening process r... |
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| Keywords: | Triethylene-glycol PEG Dicoumarin SRB Cytotoxicity test |
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