An approach to an enantioselective synthesis of crisamicin A via a novel double Hauser-Kraus annulation strategy |
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| Authors: | Olivier Andrey |
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| Affiliation: | Department of Chemistry, The University of Auckland, 23 Symonds Street, Auckland, New Zealand |
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| Abstract: | ![]()
A double Hauser-Kraus annulation between biscyanophthalide 4 and the d-mannose derived enone 39 provides access to an advanced intermediate 54 that is an excellent scaffold to effect an enantioselective total synthesis of crisamicin A 1. |
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| Keywords: | Pyranonaphthoquinone antibiotics Crisamicin A Hauser-Kraus annulation |
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