| 两亲性嵌段共聚物PGMA-b-PMAPEG的制备及其胶束的布洛芬药物控制释放性能 |
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| 引用本文： | 李东风,张艳丽,刘学军,袁金芳. 两亲性嵌段共聚物PGMA-b-PMAPEG的制备及其胶束的布洛芬药物控制释放性能[J]. 化学研究, 2011, 22(6): 34-38 |
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| 作者姓名： | 李东风 张艳丽 刘学军 袁金芳 |
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| 作者单位： | 河南大学化学化工学院,河南开封,475004 |
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| 基金项目： | 河南省教育厅自然科学研究资助项目(2011B150004) |
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| 摘 要： | 利用自由基可逆加成-断链链转移(RAFT)活性/可控聚合法成功合成了两亲性嵌段共聚物聚(甲基丙烯酸缩水甘油酯)-b聚(甲基丙烯酸聚乙二醇酯)(PGMA-b-PMAPEG).利用傅立叶变换红外光谱、核磁共振谱仪、凝胶渗透色谱仪及透射电镜等分析了所合成聚合物的结构、胶束粒径及形貌.以布洛芬作为模型药物负载于聚合物胶束内,考...
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| 关 键 词： | 两亲性嵌段共聚物 胶束 制备 布洛芬 控制释放性能 |
Preparation of an amphiphilic block copolymer PGMA-b-PMAPEG and evaluation of its drug-releasing behavior for controlled release of ibuprofen |
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| LI Dong-feng,ZHANG Yan-li,LIU Xue-jun,YUAN Jin-fang. Preparation of an amphiphilic block copolymer PGMA-b-PMAPEG and evaluation of its drug-releasing behavior for controlled release of ibuprofen[J]. Chemical Research, 2011, 22(6): 34-38 |
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| Authors: | LI Dong-feng ZHANG Yan-li LIU Xue-jun YUAN Jin-fang |
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| Affiliation: | LI Dong-feng,ZHANG Yan-li,LIU Xue-jun,YUAN Jin-fang (College of Chemistry and Chemical Engineering,Henan University,Kaifeng 475004,Henan,China) |
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| Abstract: | Amphiphilic block copolymer,poly(glycidyl methacrylate)-block-poly(methacrylic acid ester of polyethylene glycol),PGMA-b-PMAPEG in short,was synthesized by reversible addition-fragmentation chain transfer(RAFT)-controlled radical polymerization.The structure of as-synthesized block copolymer as well as the morphology and size of its micelle were analyzed by means of Fourier transform infrared spectrometry,nuclear magnetic resonance spectroscopy,gel permeation chromatography,and transmission electron microsc... |
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| Keywords: | amphiphilic block copolymer micelle preparation ibuprofen controlled release behavior |
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