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Mannose‐6‐Phosphate Receptor: A Target for Theranostics of Prostate Cancer |
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| Authors: | Dr Ophélie Vaillant Dr Khaled El Cheikh Dr David Warther Dr David Brevet Dr Marie Maynadier Dr Elise Bouffard Dr Frédéric Salgues Dr Audrey Jeanjean Dr Pierre Puche Dr Catherine Mazerolles Dr Philippe Maillard Dr Olivier Mongin Dr Mireille Blanchard‐Desce Dr Laurence Raehm Dr Xavier Rébillard Dr Jean‐Olivier Durand Dr Magali Gary‐Bobo Dr Alain Morère Dr Marcel Garcia |
| Institution: | 1. Institut des Biomolécules Max Mousseron, UMR 5247 CNRS, UM 1, UM 2‐Faculté de Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier cedex 05 (France);2. Institut Charles Gerhardt Montpellier, UMR‐5253 CNRS‐UM2‐ENSCM‐UM1 cc 1701, Place Eugène Bataillon, F‐34095 Montpellier cedex 05. (France);3. NanoMedSyn, Faculté de Pharmacie, Montpellier cedex 05 (France);4. Institut chirurgie viscérale, Clinique mutualiste Beau‐Soleil, 119 avenue de Lodève, 34070 Montpellier (France);5. Service d'Anatomie pathologique et Histologie‐Cytologie, P?le Biologie, H?pital de Rangueil, Toulouse cedex 9 (France);6. Institut Curie, CNRS UMR 176, Orsay (France);7. Institut Des Sciences Chimiques de Rennes, CNRS UMR 6226 Université Rennes 1, Campus Beaulieu, Rennes Cedex (France);8. Univ. Bordeaux, Institut des Sciences Moléculaires, UMR CNRS 5255, Talence Cedex (France);9. Service d'urologie, Clinique mutualiste Beau‐Soleil, Montpellier (France) |
| Abstract: | The development of personalized and non‐invasive cancer therapies based on new targets combined with nanodevices is a major challenge in nanomedicine. In this work, the over‐expression of a membrane lectin, the cation‐independent mannose 6‐phosphate receptor (M6PR), was specifically demonstrated in prostate cancer cell lines and tissues. To efficiently target this lectin a mannose‐6‐phosphate analogue was synthesized in six steps and grafted onto the surface of functionalized mesoporous silica nanoparticles (MSNs). These MSNs were used for in vitro and ex vivo photodynamic therapy to treat prostate cancer cell lines and primary cell cultures prepared from patient biopsies. The results demonstrated the efficiency of M6PR targeting for prostate cancer theranostic. |
| Keywords: | cancer carbohydrates nanoparticles receptors synthesis design |