Stereoselective Nickel‐Catalyzed [2+2] Cycloadditions of Ene‐Allenes |
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| Authors: | Njamkou N. Noucti Prof. Erik J. Alexanian |
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| Affiliation: | Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (USA) |
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| Abstract: | A stereoselective nickel‐catalyzed [2+2] cycloaddition of ene‐allenes is reported. This transformation encompasses a broad range of ene‐allene substrates, thus providing efficient access to fused cyclobutanes from easily accessed π‐components. A simple and inexpensive first‐row catalytic system comprised of [Ni(cod)2] and dppf was used in this process, thus constituting an attractive approach to synthetically challenging cyclobutane frameworks under mild reaction conditions. |
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| Keywords: | alkenes allenes carbocycles cycloaddition nickel |
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