A Palladium(II)‐Catalyzed CH Activation Cascade Sequence for Polyheterocycle Formation |
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| Authors: | Stephen P Cooper Prof?Dr Kevin I Booker‐Milburn |
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| Institution: | School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS (UK) http://www.chm.bris.ac.uk/org/bmilburn/index2.htm |
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| Abstract: | Polyheterocycles are found in many natural products and are useful moieties in functional materials and drug design. As part of a program towards the synthesis of Stemona alkaloids, a novel palladium(II)‐catalyzed C? H activation strategy for the construction of such systems has been developed. Starting from simple 1,3‐dienyl‐substituted heterocycles, a large range of polycyclic systems containing pyrrole, indole, furan and thiophene moieties can be synthesized in a single step. |
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| Keywords: | C H activation domino reactions heterocycles homogeneous catalysis palladium |
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