Direct Catalytic Enantio‐ and Diastereoselective Ketone Aldol Reactions of Isocyanoacetates |
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| Authors: | Dr. Raquel de la Campa Dr. Irene Ortín Prof. Dr. Darren J. Dixon |
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| Affiliation: | Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA (UK) |
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| Abstract: | ![]()
A catalytic asymmetric aldol addition/cyclization reaction of unactivated ketones with isocyanoacetate pronucleophiles has been developed. A quinine‐derived aminophosphine precatalyst and silver oxide were found to be an effective binary catalyst system and promoted the reaction to afford chiral oxazolines possessing a fully substituted stereocenter with good diastereoselectivities and excellent enantioselectivities. |
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| Keywords: | aldol reaction asymmetric catalysis enantioselectivity isocyanoacetates oxazolines |
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