Cooperative Catalysis: Enantioselective Propargylic Alkylation of Propargylic Alcohols with Enecarbamates Using Ruthenium/Phosphoramide Hybrid Catalysts |
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| Authors: | Yasushi Senda Dr Kazunari Nakajima Prof Dr Yoshiaki Nishibayashi |
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| Institution: | Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Bunkyo‐ku, Tokyo 113‐8656 (Japan) |
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| Abstract: | The diastereo‐ and enantioselective propargylic alkylation of propargylic alcohols with E‐enecarbamates in the presence of a catalytic amount of thiolate‐bridged diruthenium complexes bearing an optically active phosphoramide moiety gives the corresponding propargylic alkylated products (up to 97 % ee). |
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| Keywords: | alkynes asymmetric catalysis organocatalyst ruthenium synthetic methods |
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