A practical synthesis of (S)-2-cyclohexyl-2-phenylglycolic acid via organocatalytic asymmetric construction of a tetrasubstituted carbon center |
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| Authors: | Tokuda Osamu Kano Taichi Gao Wei-Guo Ikemoto Tetsuya Maruoka Keiji |
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| Institution: | Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Japan. |
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| Abstract: | reaction: see text] A concise and enantioselective synthesis of (S)-2-cyclohexyl-2-phenylglycolic acid as a key intermediate for (S)-oxybutynin is reported. The crucial asymmetric tetrasubstituted carbon center was constructed with excellent stereoselectivity through the proline-catalyzed direct asymmetric aldol reaction between cyclohexanone and ethyl phenylglyoxylate under mild conditions. |
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