Synthesis and study of (2S,4S)-4-arylamino-2-carboxy-5-pyrrolidones |
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| Authors: | V P Krasnov I A Nizova T A Sinitsyna N V Avdyukova |
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| Institution: | (1) Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 20 ul. S. Kovalevskoi, 620219 Ekaterinburg, Russian Federation |
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| Abstract: | (2S,4S)-4-Arylamino-2-carboxy-5-pyrrolidones were prepared by hydrolysis of dimethyl (2S,4S)-4-arylamino-N-phthaloylglutamates. The protonation constants of the arylamino group in the synthesized compounds were determined. The pyrrolidone ring is stable in acidic or neutral solutions. The relative stability of the pyrrolidone ring in alkaline solutions was studied by IR spectroscopy.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2087–2090, December, 1993. |
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| Keywords: | glutamic acid acid dissociation constants 4-arylaminopyroglutamic acid |
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