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| dl-六甲基化丹酚酸A甲酯的合成 | |
| 引用本文： | 童元峰,程永浩,郭晓赟,吴松. dl-六甲基化丹酚酸A甲酯的合成[J]. 合成化学, 2007, 15(2): 169-172 |
| 作者姓名： | 童元峰 程永浩 郭晓赟 吴松 |
| 作者单位： | 中国医学科学院,中国协和医科大学,药物研究所,北京,100050;中国医学科学院,中国协和医科大学,药物研究所,北京,100050;中国医学科学院,中国协和医科大学,药物研究所,北京,100050;中国医学科学院,中国协和医科大学,药物研究所,北京,100050 |
| 摘 要： | 以2,3二-甲氧基苯甲醛为原料,经还原、溴化、Wittig反应、在正丁基锂作用下醛基化、Knoevenagel反应生成四甲基化丹酚酸F(9),9再与草酰氯反应成酰氯后与甲基化丹参素甲酯反应得到dl-六甲基化丹酚酸A甲酯,其结构经1HNMR和MS表征,总收率44.7%。 |
| 关 键 词： | 丹酚酸 丹酚酸甲酯 药物合成 |
| 文章编号： | 1005-1511（2007）02-0169-04 |
| 收稿时间： | 2006-05-12 |
| 修稿时间： | 2006-05-12 |
Synthesis of Hexamethyl Ether of Salvianolic Acid A Methyl Ester |
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| TONG Yuan-feng,CHENG Yong-hao,GUO Xiao-yun,WU Song. Synthesis of Hexamethyl Ether of Salvianolic Acid A Methyl Ester[J]. Chinese Journal of Synthetic Chemistry, 2007, 15(2): 169-172 | |
| Authors: | TONG Yuan-feng CHENG Yong-hao GUO Xiao-yun WU Song |
| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
| Abstract: | Tetramethyl salvianolic acid F(9) was synthesized from 2,3-dihydroxybenzaldehyde by reduction, bromination,Wittig reaction,formation of aldehyde group with n-BuLi and Knoevenagel reaction.Hexamethyl ether of salvianolic acid A methyl ester(1) in overall yield of 44.7% was synthesized by 9 reacting with oxalyl chloride and then reacting with 3-(3,4-dimethoxyphenyl)lactic acid methyl ester.The structures were identified by 1H NMR and MS. |
| Keywords: | salvianolic acid F salvianolic acid A methyl ester drug synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |