Studies of the kinetics of the reduction of chromate by glutathione and related thiols |
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Authors: | Paul O'Brien Guofang Wang and Peter B Wyatt |
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Institution: | Department of Chemistry, Queen Mary and Westfield College, University of London, Mile End Road, London E1 4NS, U.K. |
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Abstract: | The reduction of chromate by glutathione, its mono- and diethyl esters,
-cysteine, 2-mercapto-propionic acid and mercapto-succinic acid has been studied. The empirical rate law kobs = abThiol]2/(1 + bThiol]) is obeyed by all of these thiols, at neutral pH. No evidence could be obtained for a first-order pathway in glutathione under these conditions. These observations are used to comment on the stability of intermediates potentially important in explaining chromate toxicity. |
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