| Molecular Spectroscopic Study on the Interaction between Heparin and Neutral Red |
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| 作者姓名： | LiZHANG NaLI FengLinZHAO KeAnLI |
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| 作者单位： | KeyLaboratoryofBioorganicChemistryandMolecularEngineeringofMinistryofEducation,DepartmentofChemicalBiology,CollegeofChemistryandMolecularEngineering,PekingUniversity,Beijing100871 |
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| 摘 要： | The interaction between heparin and neutral red was investigated by molecular spectroscopic methods. The change of all spectra suggested that positively charged neutral red had interacted with negatively charged heparin. The study of influence factors indicated that electrostatic force and hydrophobic bond might be involved in the interaction. The total binding number per disaccharide unit and intrinsic binding constant were obtained using Scatchard model.
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| 关 键 词： | 分子光谱 肝素 中性红 相互作用 |
Molecular Spectroscopic Study on the Interaction between Heparin and Neutral Red |
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| LiZHANG NaLI FengLinZHAO KeAnLI.Molecular Spectroscopic Study on the Interaction between Heparin and Neutral Red[J].Chinese Chemical Letters,2004,15(6):671-674. |
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| Authors: | Li ZHANG Na LI Feng Lin ZHAO Ke An LI
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education |
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| Institution: | Li ZHANG,Na LI,Feng Lin ZHAO,Ke An LI
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,Department of Chemical Biology,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871 |
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| Abstract: | The interaction between heparin and neutral red was investigated by molecular spectroscopic methods. The change of all spectra suggested that positively charged neutral red had interacted with negatively charged heparin. The study of influence factors indicated that electrostatic force and hydrophobic bond might be involved in the interaction. The total binding number per disaccharide unit and intrinsic binding constant were obtained using Scatchard model. |
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| Keywords: | Spectroscopic interaction heparin neutral red |
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