| 无溶剂条件下合成2-[3-氧代-1,3-二(未)取代苯基丙基]-1,2,3,4-四氢萘-1-酮 |
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| 引用本文： | 荣良策,韩红霞,蒋虹,李小跃,姚昌盛,屠树江.无溶剂条件下合成2-[3-氧代-1,3-二(未)取代苯基丙基]-1,2,3,4-四氢萘-1-酮[J].有机化学,2008,28(4):746-749. |
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| 作者姓名： | 荣良策 韩红霞 蒋虹 李小跃 姚昌盛 屠树江 |
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| 作者单位： | [1]徐州师范大学化学化工学院,徐州221116 [2]江苏省药用植物生物技术重点实验室,徐州221116 |
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| 基金项目： | 国家自然科学基金(No.20772103)、徐州师范大学自然科学基金(No.06XLA09)资助项目. |
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| 摘 要： | 以3,4-二氢-1-萘酮和查尔酮为原料, 在 K2CO3-NaOH 存在下, 无溶剂室温研磨反应, 方便地得到2-3-氧代-1,3-二(未)取代苯基丙基]-1,2,3,4-四氢萘-1-酮. 该方法具有反应条件温和、操作简单和产率较高等优点, 并通过IR, 1H NMR, 元素分析确定了产物的结构, 3b晶体结构通过X衍射测定.
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| 关 键 词： | 1-四氢萘酮 查尔酮 无溶剂 合成 |
| 收稿时间： | 2007-6-20 |
| 修稿时间： | 2007年6月20日 |
Synthesis of 2-{3-Oxo-1,3-di[(un)substituted phenyl]pro-pyl}-1,2,3,4-tetrahydronaphthalen-1-ones under Solvent-Free Condi-tion |
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| RONG Liang-Ce.Synthesis of 2-{3-Oxo-1,3-di[(un)substituted phenyl]pro-pyl}-1,2,3,4-tetrahydronaphthalen-1-ones under Solvent-Free Condi-tion[J].Chinese Journal of Organic Chemistry,2008,28(4):746-749. |
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| Authors: | RONG Liang-Ce |
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| Institution: | ( College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116)( Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou 221116) |
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| Abstract: | The synthesis of 2-{3-oxo-1,3-di(un)substituted phenyl]propyl}-1,2,3,4-tetrahydronaphthalen- 1-ones from chalcones and 1-tetralone was carried out in excellent yields in the presence of K2CO3-NaOH under a solvent-free condition at room temperature using a grinding method. This protocol has the advantages of mild reaction conditions, simple procedure and high yields. The structures of the products were characterized on the basis of IR, 1H NMR spectroscopic data, elemental analysis, and that of 3b was additionally confirmed by X-ray diffraction analysis. |
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| Keywords: | 1-tetralone chalcone solvent-free synthesis |
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