Synthesis of 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]-1,2,4-triazole-3- and 5-carboxamides |
| |
| Authors: | Tai-Shun Lin Mao-Chin Liu |
| |
| Institution: | Department of Pharmacology and Comprehensive Cancer Center Yale University School of Medicine New Haven, Connecticut 06510 USA |
| |
| Abstract: | Coupling of trimethylsilyl derivative of methyl 1,2,4-triazole-3-carboxylate with 2--(chloromethyl)-1,3-di--benzyl glycerol, followed by amination and removal of the protecting groups afforded 1-(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]-1,2,4-triazole 3- and 5-carboxamides, 1a and 1b, respectively. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
