lα-hydroxy previtamin D<sub>3</sub>, and its selective formation from 1-keto previtamin D<sub>3</sub>期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

lα-hydroxy previtamin D₃, and its selective formation from 1-keto previtamin D₃

Authors:	L.J. Vanmaele P.J. De Clercq M. Vandewalle S.J. Halkes W.R.M. Overbeek

Affiliation:	1. A Department of Organic Chemistry, State University of Ghent, Laboratory for Organic Synthesis, Krijgslaan, 281 (S.4), B-9000 GENT Belgium;2. Duphar BV, P.O. Box, 2, 1380 AA WEESP Holland, U.S.A.

Abstract:	An efficient method for the preparation of crystalline α-hydroxy previtamin D₃ is described. Also the stereoselective reduction of 1-keto previtamin $9$ is discussed; it was observed that with aluminum hydride $7$ is the most abundant product. This stands in contrast with previously reported LiAlH₄ and NaBH₄ mediated reductions.

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