A vicarious aromatic substitution approach to aklavinone from chrysazin |
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| Authors: | Raymond A. Murphy Michael P. Cava |
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| Affiliation: | Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104 U.S.A. |
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| Abstract: | ![]()
The cheap, available dye-intermediate 1,8-dihydroxyanthraquinone (2) is converted efficiently to a useful aklavinone precursor (3). A Mitsunobu alkylation-Claisen rearrangement sequence and an unprecedented vicarious aromatic substitution on an anthraquinone are employed as key steps. |
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