Microwave-assisted synthesis of a triazole-linked 3′-5′ dithymidine using click chemistry |
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| Authors: | Romain Lucas Amel Hadj Bouazza Robert Granet Yves Champavier |
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| Affiliation: | a Laboratoire de Chimie des Substances Naturelles EA1069, Faculté des Sciences et Techniques, 123 Avenue Albert Thomas, F-87060 Limoges, France
b Université de Limoges, Service Commun de RMN, Faculté de Pharmacie, 2 rue du Dr Marcland, F-87025 Limoges, France |
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| Abstract: | Synthesis of a triazole-linked 3′-5′ thymidine dimer making use of 1,3-dipolar cycloaddition is described. The azido-precursor was obtained by regioselective chlorination of thymidine, followed by azidation. The second precursor, a propargyl derivative, was obtained by selective 3′-O-alkylation of thymidine. Two ‘click systems’ were compared to obtain the desired dimer. These reactions were performed by microwave irradiation. |
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| Keywords: | Dithymidine Click chemistry Microwave Selective chlorination |
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