| One-pot Copper Nanoparticle-catalyzed Synthesis of Imidazo[1,2-α]pyridines Under Solvent-free Conditions |
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| 基金项目： | Supported by the National Natural Science Foundation of China（Nos.20772088, 21172163） and the Priority Academic Program Development of Jiangsu Higher Education Institutions. |
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| 摘 要： | A direct and efficient approach to synthesize imidazo[1,2-α]pyridines through three-component one-pot reaction of 2-aminopyridine,aldehyde and terminal alkyne catalyzed by Cu-nanoparticles under solvent-free conditions has been developed.This method provides a rapid access to substituted imidazo[1,2-α]pyridines with good yields（up to 85％）.
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| 关 键 词： | 2-氨基吡啶 无溶剂条件 催化合成 取代咪唑 一锅反应 铜纳米粒子 铜纳米颗粒 快速访问 |
One-pot Copper Nanoparticle-catalyzed Synthesis of Imidazo[1,2-a]pyridines Under Solvent-free Conditions |
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| ZONG Chenglong ZENG Runsheng ZOU Jianping. One-pot Copper Nanoparticle-catalyzed Synthesis of Imidazo[1,2-a]pyridines Under Solvent-free Conditions[J]. Chemical Research in Chinese University, 2014, 30(4): 632-638. DOI: 10.1007/s40242-014-3520-5 |
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| Authors: | ZONG Chenglong ZENG Runsheng ZOU Jianping |
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| Affiliation: | Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China |
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| Abstract: | A direct and efficient approach to synthesize imidazo[1,2-a]pyridines through three-component one-pot reaction of 2-aminopyridine, aldehyde and terminal alkyne catalyzed by Cu-nanoparticles under solvent-free conditions has been developed. This method provides a rapid access to substituted imidazo[1,2-a]pyridines with good yields(up to 85%). |
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| Keywords: | Copper nanoparticle Three-component reaction Solvent-free condition 2-Aminopyridine Aldehyde Alkyne |
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