Asymmetric synthesis of bioactive hydrodibenzofuran alkaloids: (-)-lycoramine, (-)-galanthamine, and (+)-lunarine |
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| Authors: | Chen Peng Bao Xu Zhang Le-Fen Ding Ming Han Xiao-Jie Li Jing Zhang Guo-Biao Tu Yong-Qiang Fan Chun-An |
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| Affiliation: | State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui Nanlu, Lanzhou 730000 (China). |
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| Abstract: | ![]()
Divergent route: A direct C?C bond-forming approach to the key aryl-substituted all-carbon quaternary stereogenic center present in bioactive hydrodibenzofuran alkaloids has been discovered. This approach involves an unprecedented organocatalytic enantioselective Michael addition of α-cyanoketones with acrylates and was used in a novel and divergent synthetic strategy for the title compounds in asymmetric fashion. |
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| Keywords: | alkaloids asymmetric synthesis Michael addition organocatalysis quaternary carbon |
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