|
|||||
|
|
Low-energy electrons and X-ray irradiation effects on plasma-polymerized allylamine bioactive coatings for stents |
|
| Authors: | Sylvain Massey,Enrico Gallino,Pierre Cloutier,Lé on Sanche,Denis Roy |
| Affiliation: | a Laboratoire de Physique Atomique et Moléculaire et Centre Québécois sur les Matériaux Fonctionnels, Département de physique, de génie physique et d'optique, Faculté des Sciences et de Génie, Université Laval, Québec, Canada G1V 0A6 b Laboratoire de Biomatériaux et de Bioingénierie et Centre Québécois sur les Matériaux Fonctionnels, Département de génie des mines, de la métallurgie et des matériaux, Faculté des Sciences et de Génie, Université Laval, Québec, Canada G1V 0A6 c Laboratoire de Génie des Procédés Plasma et Traitements de Surface, École Nationale Supérieure de Chimie de Paris, Chimie ParisTech, 11 rue Pierre et Marie Curie, 75005 Paris Cedex, France d Département de médecine nucléaire et radiobiologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Canada J1H 5N4 |
| Abstract: | Radiation used in biomedical applications causes chemical changes to biomedical materials. This work is an ex situ simulation of the influence of low-energy electron (LEE) impact and X-ray irradiation on the chemical properties of plasma-polymerized allylamine (PPA) bioactive and biocompatible stent coatings. Preliminary X-ray photoelectron spectroscopy (XPS) results show that PPA coatings oxidize in contact with ambient air by the detection of C-O and C O bonds which are typical of polymer oxidation. Chemical changes after LEE and X-ray irradiation are mainly a loss of oxygen, assuming a surface deoxidizing and not a complete destruction of the surface. XPS survey analyses show that the amine groups remain stable during irradiation. LEE impact measurements by TOF mass spectrometry show that the main ionic losses are H− ions. It appears that CN groups are stable under irradiation and we observe a loss of hydrogen and oxygen as the main chemical modifications. In conclusion, these results suggest that PPA coatings are stable under biomedical radiation, and they can therefore be used for bioactive and biocompatible stent coatings. |
| Keywords: | Allylamine Plasma coating Low-energy electron impact X-ray irradiation X-ray photoelectron spectroscopy |
| 本文献已被 ScienceDirect 等数据库收录！ | |