Water soluble cyclodextrin polymers: Their interaction with drugs |
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| Authors: | J. Szeman E. Fenyvesi J. Szejtli H. Ueda Y. Machida T. Nagai |
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| Affiliation: | (1) Chinoin Pharmaceutical and Chemical Works Ltd., Endrödi S- u. 38/40, H-1026 Budapest, Hungary;(2) Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, 142 Shinagawa-ku. Tokyo, Japan |
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| Abstract: | The complex forming ability of a water-soluble  -cyclodextrin epichlorohydrin, polymer (CDPS) and its different molecular weight fractions was studied and compared with the complexing properties of -cyclodextrin (CD) and dimethyl-CD (DM-CD). CDPS was separated into two main fractions. CDPS and its fractions formed well soluble inclusion compounds with the studied drugs. The low molecular weight fraction formed rather stable complexes with small guest molecules, the high molecular weight fraction was found to be more efficient in binding larger substrates. Structural studies of furosemide-CD complexes were attempted by NMR spectroscopy.Presented at the Fourth International Symposium on Inclusion Phenomena and the Third International Symposium on Cyclodextrins, Lancaster, U.K., 20–25 July 1986. |
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| Keywords: | Cyclodextrin polymer solubility method complex stability NMR spectroscopy |
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