Exploiting C3-symmetry in the dynamic coordination of a chiral trisoxazoline to copper(II): improved enantioselectivity, and catalyst stability in asymmetric lewis acid catalysis |
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| Authors: | Foltz Carole Stecker Björn Marconi Guido Bellemin-Laponnaz Stéphane Wadepohl Hubert Gade Lutz H |
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| Affiliation: | Anorganisch-Chemisches Institut, Universit?t Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany. |
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| Abstract: | Chiral C3-symmetric trisoxazolines are highly efficient stereodirecting ligands in enantioselective Cu(II) Lewis acid catalysis which is based on the concept of a stereoelectronic hemilability of the divalent copper; in direct comparison with the analogous bisoxazoline systems they are more efficient in the enantioselective alpha-amination as well as the enantioselective Mannich reaction of prochiral beta-ketoesters. |
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