新型金属卟啉的合成及其对大肠杆菌生长代谢的抑制作用

以5，10，15，20-四（对羟基苯基）卟啉（2）为原料，合成并表征了一系列 水溶性和非水溶性的金属卟啉。使用LKB 2277热活性监测器测定了大肠杆菌在金属 卟啉4a ～ 4f和7a ～ 7f作用下的生热曲线，得到了不同金属卟啉在不同浓度下大 肠杆菌生长代谢的生热速率常数k，最大发热功率p_(max)和最大发热功率的出现时 间t。结果发现，含有吡啶溴化盐的水溶性金属卟啉7a ～ 7f对大肠杆菌生长代谢 的抑制活性要明显大于含有酯基的金属卟啉4a ～ 4f。

Synthesis of Novel Metalloporphyrins and Their Action on the Growth Metabolism of E. coli

Based on 5,10,15,20-tetrakis (4-hydroxyphenyl) porphyrin (2), a series of water insoluble and water-soluble metalloporphyrins has been synthesized. An LKB-227 thermal activity monitor was used to monitor the cell metabolic activity in vitro to produce thermogenesis curves. The growth rate constants k, maximum heat production rates p_(max) and peak time of growth thermogenic curves t of E. coli in different metalloporphyrins at different concentrations were deduced from these thermogenesis curves. Metalloporphyrins 4a ～ 4f and 7a ～ 7f show inhibiting action on the growth metabolism of E. coli with water- soluble metalloporphyrins 7a ～ 7f being the better ones.