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Antibacterial Nanomaterials: Mechanisms,Impacts on Antimicrobial Resistance and Design Principles |
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| Authors: | Maomao Xie Meng Gao Yang Yun Martin Malmsten Vincent M Rotello Radek Zboril Omid Akhavan Aliaksandr Kraskouski John Amalraj Xiaoming Cai Jianmei Lu Huizhen Zheng Ruibin Li |
| Institution: | 1. State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou Medical College, Soochow University, Suzhou, 215123 Jiangsu, China
These authors contributed equally to this work.;2. State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou Medical College, Soochow University, Suzhou, 215123 Jiangsu, China;3. College of Environmental & Resource Sciences, Shanxi University, Taiyuan, 030006 Shanxi, China These authors contributed equally to this work.;4. Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark;5. Department of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, USA;6. Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute (CATRIN), Palacký University Olomouc, Šlechtitelů 241/27, Olomouc, 783 71 Czech Republic;7. Condensed Matter National Laboratory, P.O. Box 1956838861, Tehran, Iran;8. Department of Physicochemistry of Thin Film Materials, Institute of Chemistry of New Materials of NAS of Belarus, 36 F. Skaryna Str., 220084 Minsk, Belarus;9. Laboratory of Materials Science, Instituto de Química de Recursos Naturales, Universidad de Talca, P.O. Box 747, Talca, Chile;10. School of Public Health, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215123 China;11. College of Chemistry, Chemical Engineering and Materials Science, National Center for International Research on Intelligent Nano-Materials and Detection Technology in Environmental Protection, Soochow University, Suzhou, 215123 China |
| Abstract: | Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR-independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure-activity relationships of antibiotics and antimicrobial nanomaterials. We then focus on nano-microbe interactions to elucidate the impacts of molecular initiating events on AMR evolution. Finally, we provide an outlook on future antimicrobial nanomaterials and propose design principles for the prevention of AMR evolution. |
| Keywords: | Antibacterial Nanomaterials Antimicrobial Resistance Killing Mechanism Nano-Bio Interaction Structure-Activity Relationship |