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A Compartmentalized Nanoreactor Formed by Interfacial Hydrogelation for Cascade Enzyme Catalytic Therapy |
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| Authors: | Xingyue He Qing Wu Chen Hou Min Hu Qigang Wang Xia Wang |
| Affiliation: | 1. School of Chemical Science and Engineering, Tongji University, Shanghai, 200092 China Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434 China These authors contributed equally to this work. Contribution: Data curation (lead), Formal analysis (lead), Methodology (lead), Writing - original draft (lead);2. School of Materials Science and Engineering, Shanghai University, Shanghai, 200444 China These authors contributed equally to this work. Contribution: Formal analysis (equal), Investigation (equal), Methodology (equal);3. Shanghai Synchrotron Radiation Facility (SSRF) from Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201204 China These authors contributed equally to this work. Contribution: Data curation (supporting), Formal analysis (supporting), Methodology (supporting), Software (supporting), Writing - original draft (supporting);4. School of Chemical Science and Engineering, Tongji University, Shanghai, 200092 China Contribution: Data curation (supporting), Formal analysis (supporting), Methodology (supporting);5. Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434 China;6. School of Chemical Science and Engineering, Tongji University, Shanghai, 200092 China |
| Abstract: | Some cellular enzymatic pathways are located within a single organelle, while most others involve enzymes that are located within multiple compartmentalized cellular organelles to realize the efficient multi-step enzymatic process. Herein, bioinspired by enzyme-mediated biosynthesis and biochemical defense, a compartmented nanoreactor (Burr-NCs@GlSOD) was constructed through a self-confined catalysis strategy with burr defect-engineered molybdenum disulfide/Prussian blue analogues (MoS2/PBA) and an interfacial diffusion-controlled hydrogel network. The specific catalytic mechanism of the laccase-like superactivity induced hydrogelation and cascade enzyme catalytic therapy were explored. The confined hydrogelation strategy introduces a versatile means for nanointerface functionalization and provides insight into biological construction of simulated enzymes with comparable activity and also the specificity to natural enzymes. |
| Keywords: | Cascade Catalysis Enzymatic Hydrogelation Interfacial Functionalization Tumor Therapy |