Elucidation of solid-state complexation in ground mixtures of cholic acid and guest compounds |
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| Authors: | Oguchi Toshio Tozuka Yuichi Hanawa Takehisa Mizutani Mayuko Sasaki Nahomi Limmatvapirat Sontaya Yamamoto Keiji |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Chiba University, Japan. toguchi@p.chiba-u.ac.jp |
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| Abstract: | ![]()
The solid-state complexation between cholic acid (CA) and either methyl p-hydroxybenzoate (MPB) or ibuprofen (IBP) was investigated. Powder X-ray diffractometry, IR spectroscopy and thermal analysis suggested the complex formation between CA and MPB as well as between CA and IBP by co-grinding method. The stoichiometry of CA-MPB was 1 : 1 while that of CA-IBP was 2 : 1, reflecting the effect of guest size on complex formation. The guest compounds were assumed to be included in the channel of complexes formed by hydrogen bonds among CA molecules. |
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