| 以1-甲基-1-甲氧基乙基为保护基的一锅法合成5-芳香二酮-1H-四氮唑 |
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| 引用本文： | 刘明明,钟东威,周家毅,周璐,叶德泳.以1-甲基-1-甲氧基乙基为保护基的一锅法合成5-芳香二酮-1H-四氮唑[J].有机化学,2012,31(8):1543-1546. |
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| 作者姓名： | 刘明明 钟东威 周家毅 周璐 叶德泳 |
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| 作者单位： | 复旦大学药学院药物化学教研室 上海201203 |
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| 摘 要： | 报道了5-芳香二酮-1H-四氮唑(2)的一锅合成法,并且首次报道了1-甲基-1-甲氧基乙基作为四氮唑氮原子的保护基团,保护与脱保护反应条件温和,操作简便,收率高,为该类化合物的合成提供了一条捷径.采用该方法共合成6个未见文献报道的5-芳香二酮-1H-四氮唑类新化合物,以用于药理活性筛选.
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| 关 键 词： | 5-芳香二酮-1H-四氮唑 1-甲基-1-甲氧基乙基 四氮唑保护 一锅合成 |
One-Pot Synthesis of 5-Aryl Diketo-1H-tetrazol Using 1-Methyl-1-methoxyethyl as Protective Group |
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| Liu Mingming
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Zhong Dongwei
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Zhou Jiayi
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Zhou Lu
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Ye Deyong.One-Pot Synthesis of 5-Aryl Diketo-1H-tetrazol Using 1-Methyl-1-methoxyethyl as Protective Group[J].Chinese Journal of Organic Chemistry,2012,31(8):1543-1546. |
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| Authors: | Liu Mingming Zhong Dongwei Zhou Jiayi Zhou Lu Ye Deyong |
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| Institution: | Liu,Mingming Zhong,Dongwei Zhou,Jiayi Zhou,Lu Ye,Deyong(Department of Medicinal Chemistry,School of Pharmacy,Fudan University,Shanghai 201203) |
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| Abstract: | One-pot reaction was reported for the synthesis of 5-aryl diketo-1H-tetrazols(2).Meanwhile,1-methyl-1-methoxyethyl(MME) as protective group of tetrazole was firstly reported.The protective and deprotective reactions were performed in moderate conditions and the new method leads to simplified process and increased productivity.Six novel 5-aryl diketo-1H-tetrazol compounds were synthesized by using this method for further biological screening. |
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| Keywords: | 5-aryl diketo-1H-tetrazol 1-methyl-1-methoxyethyl(MME) tetrazole protection one-pot synthesis |
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